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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSC1 All Species: 19.09
Human Site: S515 Identified Species: 52.5
UniProt: Q92574 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92574 NP_000359.1 1164 129767 S515 Y R D S L P G S Q R K T H S A
Chimpanzee Pan troglodytes XP_520334 1163 129674 S514 Y R D S L P G S Q R K T H S A
Rhesus Macaque Macaca mulatta XP_001103589 1163 129467 S514 N R E S L P G S Q R K T H S A
Dog Lupus familis XP_537808 1169 129668 C515 Y P D S L P G C P R K T H S A
Cat Felis silvestris
Mouse Mus musculus Q9EP53 1161 128727 S512 Y R D S L S G S Q R K T H S A
Rat Rattus norvegicus Q9Z136 1163 129004 S515 Y R D S L S G S Q R K T H S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415449 1156 128927 K518 N L S G S Q K K T Q S V V S S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001119992 1001 113305 S436 M S G S L I G S G N A N N A H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190249 1454 159903 G582 L I R H L S D G H L R S D D A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.1 89.3 N.A. 87.2 86.4 N.A. N.A. 76.3 N.A. N.A. N.A. N.A. 23.5 N.A. 25.9
Protein Similarity: 100 99.6 98.7 93.5 N.A. 92 91.4 N.A. N.A. 84.7 N.A. N.A. N.A. N.A. 43.2 N.A. 43.3
P-Site Identity: 100 100 86.6 80 N.A. 93.3 93.3 N.A. N.A. 6.6 N.A. N.A. N.A. N.A. 26.6 N.A. 13.3
P-Site Similarity: 100 100 93.3 80 N.A. 93.3 93.3 N.A. N.A. 20 N.A. N.A. N.A. N.A. 40 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 12 0 0 12 78 % A
% Cys: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % C
% Asp: 0 0 56 0 0 0 12 0 0 0 0 0 12 12 0 % D
% Glu: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 12 0 0 78 12 12 0 0 0 0 0 0 % G
% His: 0 0 0 12 0 0 0 0 12 0 0 0 67 0 12 % H
% Ile: 0 12 0 0 0 12 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 12 12 0 0 67 0 0 0 0 % K
% Leu: 12 12 0 0 89 0 0 0 0 12 0 0 0 0 0 % L
% Met: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 23 0 0 0 0 0 0 0 0 12 0 12 12 0 0 % N
% Pro: 0 12 0 0 0 45 0 0 12 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 12 0 0 56 12 0 0 0 0 0 % Q
% Arg: 0 56 12 0 0 0 0 0 0 67 12 0 0 0 0 % R
% Ser: 0 12 12 78 12 34 0 67 0 0 12 12 0 78 12 % S
% Thr: 0 0 0 0 0 0 0 0 12 0 0 67 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 12 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 56 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _